What Is Bone Marrow Transplant? A Complete Guide for Nigerian Patients

A bone marrow transplant may be a life-saving treatment option for patients with severe blood diseases, cancer or inherited disorders like sickle cell disease in Nigeria.

What Is Bone Marrow Transplant? A Complete Guide for Nigerian Patients

A bone marrow transplant may be a life-saving treatment option for patients with severe blood diseases, cancer or inherited disorders like sickle cell disease in Nigeria. There are numerous families that are interested in learning more about what is involved with bone marrow transplant, who should receive it, how it is performed and what the process of recovery will be like. The experienced hematologists, specialized transplant centers, modern hospitals and comparatively low treatment costs in India are making the country a significant choice for international patients to receive advanced bone marrow transplant treatment at a significantly reduced cost. Here you will get a complete guide about bone marrow transplantation, who is eligible for it, its risks, recovery and the cost of bone marrow transplant in India.

What is Bone Marrow Transplant?

Bone marrow (or haematopoietic stem cell) transplantation (BMT) is a medical procedure in which the bone marrow is replaced with healthy bone marrow.

Bone marrow is the soft tissue found within some bones which makes blood cells including:

  • RBCs that transport oxygen.
  • Blood cells that act as a defence against infection.
  • Blood platelets that help to stop bleeding.

Damage to the bone marrow from cancer, genetic disorders, chemotherapy or other illnesses can cause it to cease to make healthy blood cells. Transplants contain healthy stem cells that can regenerate the blood and immune system. In some cases, where other treatments or medications are not effective, bone marrow transplant treatment may be suggested for patients from Nigeria.

Why is it necessary to have a bone marrow transplant?

Bone marrow transplants can be used to treat a variety of serious blood, bone marrow and immune system disorders.

BMT is used to treat a wide variety of conditions such as:

  • Sickle cell disease.
  • Leukemia (acute myeloid leukemia, acute lymphoblastic leukemia).
  • Lymphoma.
  • Multiple myeloma.
  • Aplastic anemia.
  • Thalassemia.
  • Myelodysplastic syndromes.
  • Some congenital immunodeficiency disorders.
  • Some genetic blood disorders.

Not all people with these diseases need transplantation. This depends on the severity of the disease, age, general health, prior history, availability of donors and recommendations of the specialist haematologist or transplant team.

Types of bone marrow transplant

There are two different kinds of bone marrow transplants.

Autologous Bone Marrow Transplant

  • A person's own marrow.
  • Before intensive treatment in an autologous transplant, the patient's own healthy stem cells are collected. These cells are stored and later returned to the patient's body after chemotherapy.
  • This type is typically seen in multiple myeloma and some lymphomas.

Allogeneic Bone Marrow Transplant

  • Bone marrow transplant using another person's marrow.
  • An allogeneic transplant is when stem cells are donated by another person. The donor can be a relative, blood relative or an anonymous volunteer with a similar tissue type.
  • The advantages of allogeneic transplantation apply to leukemia, severe aplastic anemia, sickle cell disease and some inherited blood disorders.
  • In carefully selected patients, an allogeneic transplant from an appropriate donor might be a potential cure for patients with sickle cell disease in Nigeria.

Who can donate bone marrow?

Before a donor can donate his or her stem cells, he or she will be medically tested to see if the stem cells will fit the recipient. The most crucial factor is matching of human leukocyte antigen (HLA). Complications like graft-versus-host disease (GVHD) are less likely to occur when there's a close HLA match.

Some potential donors can be:

  • Brothers or sisters.
  • In some cases parents.
  • Other relatives.
  • Unrelated matched donors.
  • Partially matched family members (haploidentical donors).

The transplant team does blood tests and matches the donor's DNA before deciding on a donor.

How Does Bone Marrow Transplant Work?

There are various stages in the transplant process to be aware of.

Step 1: Medical Evaluation

The patient is carefully assessed prior to transplantation. This may include:

  • Blood tests.
  • Bone marrow examination.
  • Imaging scans.
  • Evaluation of heart and lung.
  • Tests of kidney and liver function.
  • Infection screening.
  • HLA matching and donor evaluation.

The doctor determines the patient's medical readiness for transplant.

Step 2: Conditioning Treatment

The patient receives a conditioning therapy prior to receiving the new stem cells. Typically, chemotherapy and occasionally radiation treatment are administered.

The aim of conditioning is to:

  • Kill unhealthy or abnormal bone marrow cells.
  • Weaken the immune system.
  • Make space for healthy donor stem cells.

The level of conditioning will depend on the type of disease and type of transplant.

Step 3: Stem Cell Infusion

  • The collected stem cells are given into a vein like a blood transfusion. This procedure is not usually considered a surgical procedure.
  • The healthy stem cells circulate in the blood to the bone marrow where they start making new blood cells.

Step 4: Engraftment and Monitoring

Once transplanted, the patient's medical team monitors him closely as the new stem cells settle into the bone marrow. This is known as engraftment. Patients are sometimes at risk of low blood counts and infection during this time.

Doctors monitor:

  • Blood cell production.
  • Signs of infection.
  • Organ function.
  • Donor cell activity.
  • Possible transplant complications.

How Long Does Bone Marrow Transplant Treatment Take?

Treatment duration will depend on the disease process and type of transplant. Most of the time, patients will be in the hospital for the transplant and early recovery phase for a few weeks. Further recovery post-discharge.

The overall medical travel plan could take several months for those who are travelling from Nigeria to India:

  • Pre-transplant investigations.
  • Donor testing.
  • Conditioning treatment.
  • Hospitalization.
  • Engraftment.
  • Follow-up consultations.

Each hospital will have a different timeline based on the individual's medical reports.

Recovery after bone marrow transplant

Bone marrow transplant recovery is a slow process. It takes time for the immune system and blood-making to return to normal.

Patients in the recovery stage may suffer from:

  • Fatigue.
  • Weakness.
  • Loss of appetite.
  • Nausea.
  • Increased risk of infections.
  • Hair loss due to chemotherapy.
  • Mouth sores.
  • Changes in blood counts.

Strict medical directions on medications, cleanliness, diet and follow-up appointments are to be taken. The post-transplant period may involve follow-up monitoring in India, depending on the recommendation of the transplant team for international patients from Nigeria.

Bone Marrow Transplant Cost in India for Nigerian Patients 

A major worry of Nigerian families is the cost of the bone marrow transplant.

The bone marrow transplant cost in India is subject to a number of factors. For international patients, the estimated cost of the procedure could range from USD 10,000 to USD 45,000 or higher and may depend on the type of transplant and the medical needs. The actual price, however, will depend on the medical reports of the patient.

Factors Affecting Bone Marrow Transplant Cost

A number of factors affect the overall treatment costs:

  • Type of transplant (either of the donor or recipient).
  • Underlying disease.
  • Donor matching and donor testing.
  • Chemotherapy or conditioning therapy.
  • Hospital room category.
  • Intensive care requirements.
  • Supportive care and medicines.
  • Blood transfusions.
  • Length of hospital stay.
  • Complications during treatment.
  • Follow-up monitoring.
  • Costs of travel and lodging.

For Nigerian patients, it is crucial to seek an in-depth treatment rate in India before making the journey.

Bone Marrow Transplant in India for Nigerian Patients

There are specialized hospitals in India having dedicated departments of hematology and bone marrow transplantation. These facilities provide specialized services for blood diseases (cancer), sickle cell disease, thalassaemia and other diseases for patients from Nigeria and other countries in Africa who need treatment at such centres.

Benefits of selecting India could be:

  • Well-trained haematologists and transplant experts.
  • Cutting edge stem cell collection and transplantation centers.
  • NABH- and internationally accredited hospitals.
  • Modern diagnostic laboratories.
  • Complete infection control systems.
  • Multidisciplinary medical teams.
  • Treatment is less expensive than in some western countries.

Patients should choose a hospital according to the medical expertise, transplant experiences, accreditation, infrastructure and personalized treatment plan.

Why choose GetWellGo for Bone Marrow Transplant in India?

GetWellGo aids Nigerian patients who need bone marrow transplant treatment to be matched with qualified physicians and best hospitals in India. The platform caters to international patients during their entire healthcare experience from appointment to recovery.

GetWellGo can help you with:

  • Medical report evaluation.
  • Choosing a doctor or hospital.
  • Treatment suggestions and cost estimates.
  • Pre-travel (online) consultations.
  • Medical visa assistance.
  • Airport transfers.
  • Accommodation arrangements.
  • Hospital appointments.
  • Language/Communication Support.
  • Patient case managers who are dedicated to their patients.
  • Recovery support from local authorities.

Before patients and families leave Nigeria for treatment in India, the team educates them on their available treatment options and supports them in making informed decisions.

Conclusion

Nigerian patients seeking advanced therapies for blood disorders and cancers may find it helpful to learn a bit more about what bone marrow transplant entails. In certain diseases, bone marrow transplantation can be used to restore healthy blood-cell production and in some cases, can be a potentially curative treatment for diseases like sickle cell disease and leukemia. India boasts of great transplant specialists, state of the art hospitals and a full range of international patient care services. The cost of bone marrow transplantation is a variable that depends on the specific treatment for each patient but if family members need to make decisions about treatment, it is important to consult early with the patient's doctor and to plan treatment properly. GetWellGo helps the patients from Nigeria to get connected with trusted doctors and hospitals in India and helps them with their treatment process from consultation to visa assistance to post treatment.

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