What Is an Autologous Stem Cell Transplant? A Guide for Nigerians

A stem cell transplant may be a crucial component of treatment for people who have blood cancer and other severe illnesses.

What Is an Autologous Stem Cell Transplant? A Guide for Nigerians

A stem cell transplant may be a crucial component of treatment for people who have blood cancer and other severe illnesses. One of the principle types is an Autologous Stem Cell Transplant where healthy stem cells are removed from the body, preserved and then transplanted back into the patient following intensive treatment.

Autologous stem cell transplant in India can help those in Nigeria who need high-level transplant care as well as access to experienced specialists, specialised transplant centres, modern diagnostic facilities and coordinated international-patient services. GetWellGo assists Nigerian patients in finding appropriate hospitals and doctors in India and handles various other medical matters.

What is an autologous stem cell transplant?

An Autologous Stem Cell Transplant is a transplant that involves the patient's own blood-forming stem cells instead of stem cells from another person.

Stem cells are harvested from a patient's blood and stored before the transplant. High dose chemotherapy or another conditioning agent is then administered to the patient that kills the cancerous cells or abnormal cells. When this treatment has been given, the stem cells that have been collected are returned to the patient's bloodstream.

The stem cells return to the bone marrow and start to give rise to new blood cells.

This is different from an allogeneic transplant since it is the patient's own cells that are used. This also means that the problem of graft-versus-host disease which can be a problem in donor stem cell transplants is not a problem with an autologous transplant.

The reason for an Autologous Stem Cell Transplant

For certain patients, who have diseases sensitive to intensive chemotherapy, an autologous transplant may be considered. It is often used to treat some types of blood cancer and is sometimes used for other conditions.

Some of the most common conditions include:

  • Multiple myeloma

  • Certain types of lymphoma

  • Some who develop blood cancers which were either relapsed or high risk survived.

  • Selected solid tumours in particular treatment scenarios

  • For selected patients, certain autoimmune and other diseases

Transplantation is applicable only when the diagnosis is known, the stage of the disease is known, previous treatment, general health, organ function, response to therapy and ability to tolerate high dose treatment are known.

The patient needs to be assessed by a transplant specialist before he or she can be recommended for the transplant.

Autologous Stem Cell Transplant Process

Typically involves multiple stages of treatment.

Initial evaluation

  • The doctor's panel evaluates the patient's diagnosis, treatment history, blood analysis, imaging reports, organ functions and health.

  • Other tests might be done to see if the person is healthy enough to receive high-dose treatment and transplant.

Stem cell mobilisation

  • The stem cells in the patient's bone marrow are mobilized into the blood stream. Usually medicines called growth factors are used sometimes in combination with chemotherapy.

  • Blood tests are done to see when there are enough stem cells to collect.

Stem cell collection

  • Apheresis is a process used to collect stem cells. The blood is pumped through a machine that removes the stem cells and then takes out the other parts of the blood before sending it back to the patient.

  • The gathered cells are processed and frozen and can be utilized later.

Conditioning treatment

  • High dose chemotherapy or other conditioning treatments are administered to the patient.

  • This is to manage or cure the underlying disease and prepare the body for the injection of stem cells.

  • High dose therapy may temporarily depress the bone marrow and the patient's blood counts may drop dramatically.

Stem cell infusion

  • The stem cells frozen in the storage bag are then re-thawed and given intravenously or via central venous catheter.

  • This infusion is typically brief and brief, compared to the conditioning phase. The cells thereafter, move to the bone marrow.

Engraftment and monitoring

  • The transplanted stem cells start to make new blood cells. This is referred to as engrafting.

  • In this period, the patients are carefully monitored as low blood count can lead to infection, anaemia and bleeding. Transfusion of blood or platelets may be needed as medicines, if clinically indicated.

Recovery after an ASCT (Autologous Stem Cell Transplant)

The recovery rate is different from person to person. Hospitalization can vary from a few weeks depending on the treatment protocol, recovery of blood counts, complications and the overall health of the patient.

Early recovery period patients may have:

  • Fatigue

  • Nausea or vomiting

  • Reduced appetite

  • Mouth sores

  • Hair loss

  • Low blood counts

  • People who are more prone to infections. 

  • Weakness

Regularly the medical team monitors blood counts and other parameters. Antibiotics, antiviral and antifungal medications, growth factors and transfusion and/or other supportive medications may also be administered as needed.

Recovery is not complete until after the discharge. Patients may require frequent check-ups, tests, medication, diets and preventative care for infections.

How long does the Recovery Take?

  • The time course varies with the disease, conditioning regimen, patient's age, overall health and complications.

  • The recovery of blood counts is usually achieved within a few weeks after infusion of stem cells but recovery may take much longer time. Fatigue or loss of physical vigor may persist for weeks or months.

  • Before arranging their return journey, patients should speak with their transplantation team about how long they should expect to be in India for treatment and recovery.

  • GetWellGo can assist international patients in arranging hospital visits, lodging, transportation, visa processing and follow-up procedures for their entire treatment plan.

Autologous Stem Cell Transplant in India

If you need specialized care for Nigerian patient then autologous stem cell transplant in India could be a good option to consider.

There are dedicated haematology, medical oncology, intensive care, blood-bank, laboratory and transplant departments in specialized hospitals and cancer centres in India. Treatment plans are chosen based on the patient's medical condition and diagnosis instead of being a standard treatment package.

This is especially critical when it comes to hospital selection as transplantation needs to be coordinated in the pre-, during and post-radiation period.

Patients in Nigeria should consider the following factors when it comes to autologous stem cell transplant in India:

  • The oncology or transplant team's experience in the transplant.

  • Hospital facilities and infection-control facilities

  • The level of intensive care available.

  • Blood and platelet support.

  • Diagnostic and lab services.

  • Accommodation facilities for foreign patients

  • Arrangements made following discharge

  • The total and full cost of treatment and inclusions

Autologous Stem Cell Transplant Cost in India

The price at which the autologous stem cell transplant is quoted in India differs from patient to patient. No one price fits all situations because these fees vary according to the disease and treatment plan, hospital, medications, length of stay, complications and other medical needs.

The factors which may affect the autologous stem cell transplant cost in India are:

  • First consultations and diagnostic tests.

  • The process of mobilising and collecting stem cells.

  • Conditioning chemotherapy

  • Preparation and preservation of stem cells.

  • Transplant procedure

  • Hospital room and nursing care

  • Medicines and supportive treatment.

  • The blood and platelets can be transfused.

  • ICU care, if required

  • Treatment of infections or complications,

  • Duration of hospitalization

  • Regular consultations and investigations are carried out.

Travel costs also have to be taken into consideration for Nigerian patients. Some of these could include flights, visa fees, lodging outside the hospital, transportation, food and loss of a family member.

With a review of medical reports, GetWellGo can help patients get an estimate of the treatment they need.

Does Autologous Transplant Work for All Patients?

No. However, an autologous transplant is not the right choice for all patients.

The choice of which treatment to pursue will depend on the nature of the disease, previous treatment, how the disease has responded, age, overall health, kidney and liver health, heart and lung health, infection status and other medical considerations.

Prior to recommending transplantation, a transplant specialist will review the patient's full medical history and investigations.

It is also important for patients to know about the complications that can occur after transplant such as infection, having very low blood counts, complications with the organ and the risk of the disease coming back. The treating medical team will discuss about the benefits and risks prior to treatment.

Preparing for Treatment in India

Those who are planning to go for treatment in India should pick up their medical records with them before travelling. These can include biopsy reports, scans of images, blood tests, previous chemotherapy history, pathology reports, discharge summaries and lists of current medicine usage.

The records of such a specialist in India could be useful to Indian healthcare providers for assessing the suitability of an autologous transplant and further tests that might be needed.

It is not only important to think about the entire treatment process but also the transplant itself. Patients should think about the length of their hospital stay, how long the recovery will take, how often they will need follow-up appointments, how they will sleep during their hospital stay and how they will get to and from the hospital.

Conclusion

An Autologous Stem Cell Transplant is performed with the patient's own blood-forming cells and is often used in certain types of blood cancers and other diseases following intensive treatment. Autologous stem cell transplant in India can help Nigerian patients gain access to specialized hospitals and experienced multidisciplinary teams that provide advanced transplant care. But the suitability for treatment and the cost of an autologous stem cell transplant in India depends on the diagnosis and treatment plan of the patient. GetWellGo also facilitates patients in Nigeria to get in touch with appropriate Indian hospitals and physicians and organises the medical consultation, process of travel, accommodation, treatment and follow-up support.

Autologous Stem Cell Transplant​ with GetWellGo

Get Well Go is regarded as a leading supplier of healthcare services. We help our Nigerian clients choose the best treatment locations that suit their needs both financially and medically.

We offer:

  • Complete transparency

  • Fair costs.

  • 24 hour availability.

  • Medical E-visas

  • Online consultation from recognized Indian experts.

  • Assistance in selecting India's top hospitals for Autologous Stem Cell Transplant.

  • Expert hematologist with a strong track record of success

  • Assistance during and after the course of treatment.

  • Language Support

  • Travel and Accommodation Services

  • Case manager assigned to every patient to provide seamless support in and out of the hospital like appointment booking

  • Local SIM Cards

  • Currency Exchange

  • Arranging Patient’s local food

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