Magnetic Activated Cell Sorting in India for Global Patients

Magnetic activated cell sorting in India provides cell separation with expert teams, advanced labs, and affordable treatment for international patients.

Magnetic Activated Cell Sorting in India for Global Patients

  • Category

    Fertility

  • Published By

    GetWellGo Team

  • Updated on

    30-Mar-2026

Magnetic Activated Cell Sorting in India

Magnetic Activated Cell Sorting (MACS) is a cell separation methodology that employs magnetic particles that are functionalized with antibodies in order to recognize and isolate particular cells with respect to surface markers.

In fertility, it is mostly applied in order to:

  • Isolate healthy sperms that have intact DNA.

  • Cleopatra. Eliminate broken or dying sperm (DNA fragmentation).

How MACS Works

It is an easy but very accurate procedure:

  • The sample of sperm is added to magnetic microbeads that are coated with antibodies.

  • Such beads bind to broken sperm cells.

  • Magnetic column is subjected to the sample.

  • Damaged sperm/weak ones are trapped, and healthy sperm are transferred.

  • IVF or ICSI is then applied to the selected sperm.

  • This is also referred to as immunomagnetic separation.

When is MACS Recommended?

Doctors in India can recommend MACS under the following situations:

  • Repeated IVF/ICSI failure

  • An increased sperm DNA fragmentation.

  • Unexplained infertility

  • Recurrent miscarriages

  • Low semen motility/morphology.

Benefits of MACS

  • Enhances fertilization and embryo quality.

  • Increases the success rates of pregnancy (by 10-15 percent in selected cases)

  • Minimizes the chances of poor sperm DNA-related miscarriage.

  • Aids in the process of screening sperm genetically.

MACS technique in India fertility

MACS are a form of sperm sorting in a laboratory environment which eliminates the damaged (apoptotic) sperms and isolates the healthy sperm with intact DNA to fertilize a target egg.

  • It involves the magnetic microbeads of Annexin V proteins.

  • These bind to sperm that are fragmented.

  • The damaged sperm is trapped by a magnetic field.

  • IVF/ICSI involves the collection of healthy sperm.

MACS application in India IVF Labs

By far, MACS is employed as a pre-ICSI procedure in India:

  • Wash and density gradient of semen.

  • MACS used in the process of eliminating damaged sperm.

  • The egg is injected with selected sperms (ICSI).

  • This enhances the quality of sperm under fertilization.

MACS treatment for male infertility India

MACS an add-on procedure that is performed in the laboratory when the process is IVF or ICSI

  • It isolates normal sperm and injured (apoptotic) sperm.

  • Is used to determine defective sperm with the help of magnetic beads and antibodies.

  • The unhealthy sperm is filtered by a magnetic field.

  • Fertilization is only done with high quality sperms.

  • This will be of particular use where the sperm DNA fragmentation is severe.

The Assistance of MACS in Male Infertility

MACS help directly to enhance the quality of sperm to be used in fertilization:

  • Eliminates dead or damaged DNA sperm.

  • Chooses functionally active sperms.

  • Enhances the healthy development of embryos.

  • It is always combined with:

  • IVF

  • or ICSI 

Advanced sperm selection techniques India

DNA damage or functional defects can be present in even sperm that appear normal when examining them with a microscope and this can influence the quality of embryo and pregnancy outcome.

Advanced methods help:

  • Choose sperm which are genetically intact.

  • Improve embryo quality

  • Increase IVF success rates

  • Reduce miscarriage risk

  • Research indicates that about 60% and above of the cases demonstrates better results using the methods.

Forms of Advanced Sperm Selection Techniques India:

MACS 

  • Deletes broken/apoptotic sperm.

  • Uses magnetic separation

  • Optimal in terms of high DNA fragmentation.

  • Among the most useful methods (positive outcome in approximately 85% of the research)

PICSI (Physiological ICSI)

  • Chooses sperm according to hyaluronic acid adhesion.

  • Simulates the natural fertilization.

  • Selects mature sperm that is of improved DNA quality.

Best for:

  • Unexplained infertility

  • Recurrent IVF failure

Intracytoplasmic Morphologically Selected Sperm Injection

  • Has a magnification of ultra-high (6000x).

  • Identifies slight structure anomalies of the sperm.

Best for:

  • Severe male infertility

  • Repeated IVF failure

Microfluidic Sperm Selection (MFSS / Zymot)

  • Uses a microchip device

  • Mimics natural sperm selection in the female reproductive tract.

Selects sperm with:

  • High motility

  • Low DNA fragmentation

Best for:

  • High DNA fragmentation

  • The selective forces of nature are non-invasive.

Zeta Potential Method

  • Chooses sperms according to surface electrical charge.

  • Sperm in their mature size are negative.

  • Less often applied and effective in certain situations.

Birefringence Technique in Sperm

  • Adapts microscopy by the use of polarized light.

  • Ranges of structurally mature sperm.

MACS IVF procedure India

Semen Collection

  • The male partner gives a sample of semen during the day of egg picking.

Initial Sperm Preparation

  • Processing of sample is done by washing and density gradient centrifugation.

  • Debrides foreign bodies and poor quality sperm.

MACS Processing (Key Step)

  • Damaged sperm cells are attached by magnetic beads.

A magnetic column is passed over the sample:

  • Defective sperm are trapped

  • Healthy sperm pass through

  • This procedure guarantees the selection of DNA-intact sperms.

Fertilization 

Selected sperm are used for:

  • Traditional IVF or better known as.

  • One sperm injected into the egg known as Intracytoplasmic Sperm Injection (ICSI).

Embryo Development

  • The eggs are left in the laboratory between 3 and 5 days to get fertilized.

  • Best embryos are selected

Embryo Transfer

  • Embryos is transferred into the uterus and made healthy.

  • After pregnancy test, it is followed in about 2 weeks.

 

Best fertility hospitals for MACS in India

Conclusion

Magnetic Activated Cell Sorting (MACS) has become a useful innovation in IVF treatment in India especially in cases of couples with male infertility or when IVF has failed several times. MACS improves the quality of fertilization and embryo development by choosing out damaged sperm and only leaves those with more intact DNA integrity to use in procedures such as Intracytoplasmic Sperm Injection. Despite the lack of necessity in all instances, MACS may boost success in patients that have excessive sperm DNA fragmentation, low embryo quality, or frequent pregnancy loss. It is also affordable and is available in high-end fertility centers all over India with qualified embryologists and thus appealing to both local and international patients. MACS a very strong help tool when applied to the appropriate clinical context and it may enhance the probability of a healthy and successful pregnancy, which is why it is a useful resource in the current fertility care.

Magnetic Activated Cell Sorting in India with GetWellGo

GetWellGo is regarded as a leading supplier of healthcare services. We help our foreign patients choose the best treatment locations that suit their needs both financially and medically.

We offer:

  • Complete transparency

  • Fair costs.

  • 24-hour availability.

  • Medical E-visas

  • Online consultation from recognized Indian experts.

  • Help in identifying India's best hospitals for Magnetic Activated Cell Sorting.

  • Expert gynaecologists with high success rate and experience.

  • Assistance during and after the course of treatment.

  • Language Support

  • Travel and Accommodation Services

  • Case manager assigned to every patient to provide seamless support in and out of the hospital like appointment booking

  • Local SIM Cards

  • Currency Exchange

  • Arranging Patient’s local food

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